High [ATP] Kinase Panel

https://www.ntrc.nl/wp-content/uploads/2014/02/Kinome-Tree-Full-Panel_small.jpgThrough our partner Carna Biosciences we are offering the high [ATP] kinase panel. This panel facilitates inhibitor-type determinations (type I, II or III) by adding optional profiling at 1 mM ATP and kinase selectivity at physiological ATP levels.

https://www.ntrc.nl/wp-content/uploads/2014/02/Kinome-Tree-high-ATP_2.jpg
Kinases Available in the high [ATP] kinase panel

The high ATP kinase panel comprises 166 human kinases (107 TKs including mutants, 59 STKs) and allows the impact of ATP concentration on kinase-inhibitory activity to be rapidly visualized and assessed. Despite the sensitivity offered by performing in vitro assays at ATP concentrations approximating Km, physiological conditions are seldom the same. Inhibitory potency and selectivity may vary with the concentration of ATP available.

Target Name Group

Source

(Carna Cat No.)

ABL (ABL1) TK 08-001
ABL (ABL1) [T315I] TK 08-093
ABL (ABL1) [E255K] TK 08-094
ACK (TNK2) TK 08-196
AKT1 STK 01-101
ALK TK 08-518
ALK[F1174L] TK 08-519
ALK[L1196M] TK 08-529
ALK[R1275Q] TK 08-520
AMPK α1/β1/γ1 (PRKAA1/B1/G1) STK 02-113
ARG (ABL2) TK 08-102
AurA (AURKA) STK 05-101
AurB (AURKB)/INCENP STK 05-102
AurC (AURKC) STK 05-103
AXL TK 08-107
BLK TK 08-164
BMX TK 08-179
BRK (PTK6) TK 08-165
BRSK1 STK 02-115
BTK TK 08-080
CaMK4 STK 02-108
CDC2 /CycB1 STK 04-102
CDC7/ASK STK 05-109
CDK2 /CycE1 STK 04-165
CDK2 /CycA2 STK 04-103
CDK4 /CycD3 STK 04-105
CDK5 /p25 STK 04-106
CDK6 /CycD3 STK 04-107
CDK7 /CycH/MAT1 STK 04-108
CDK9 /CycT1 STK 04-110
CHK1 (CHEK1) STK 02-117
CHK2 (CHEK2) STK 02-162
CK1α (CSNK1A1) STK 03-101
CK1ε (CSNK1E) STK 03-104
CK2α1/β (CSNK2A1/B) STK 05-184
CSK TK 08-111
DAPK1 STK 02-134
DDR1 TK 08-113
DDR2 TK 08-114
DYRK1B STK 04-131
EGFR TK 08-115
EGFR[d746-750/T790M] TK 08-528
EGFR[d746-750] TK 08-527
EGFR[L858R] TK 08-502
EGFR[L861Q] TK 08-513
EGFR[T790M/L858R] TK 08-510
EGFR[T790M] TK 08-194
EML4-ALK TK 08-516
EPHA1 TK 08-119
EPHA2 TK 08-121
EPHA3 TK 08-122
EPHA4 TK 08-123
EPHA5 TK 08-124
EPHA6 TK 08-125
EPHA7 TK 08-126
EPHA8 TK 08-127
EPHB1 TK 08-128
EPHB2 TK 08-129
EPHB3 TK 08-130
EPHB4 TK 08-131
Erk1 (MAPK3) STK 04-142
Erk2 (MAPK1) STK 04-143
FAK (PTK2) TK 08-137
FER TK 08-139
FES TK 08-140
FGFR1 TK 08-133
FGFR2 TK 08-134
FGFR3 TK 08-135
FGFR3[K650E] TK 08-501
FGFR3[K650M] TK 08-199
FGFR4 TK 08-136
FGFR4[N535K] TK 08-524
FGFR4[V550E] TK 08-525
FGFR4[V550L] TK 08-526
FGR TK 08-166
FLT1 TK 08-189
FLT3 TK 08-154
FLT4 TK 08-190
FMS (CSF1R) TK 08-155
FRK TK 08-167
FYN TK 08-068
GSK3α (GSK3A) STK 04-140
GSK3β (GSK3B) STK 04-141
HCK TK 08-169
HER2 (ERBB2) TK 08-016
HER4 (ERBB4) TK 08-118
HGK (MAP4K4) STK 07-137
IGF1R TK 08-141
IKKβ (IKBKB) STK 05-084
INSR TK 08-142
IRR (INSRR) TK 08-143
ITK TK 08-181
JAK1 TK 08-144
JAK2 TK 08-045
JAK3 TK 08-046
JNK1 (MAPK8) STK 04-163
JNK2 (MAPK9) STK 04-164
JNK3 (MAPK10) STK 04-150
KDR TK 08-191
KIT TK 08-156
KIT[D816V] TK 08-505
KIT[T670I] TK 08-195
KIT[V560G] TK 08-504
KIT[V654A] TK 08-511
LCK TK 08-170
LTK TK 08-106
LYNa TK 08-171
LYNb TK 08-172
MAPKAPK2 STK 02-142
MER (MERTK) TK 08-108
MET TK 08-151
MET[Y1235D] TK 08-198
MST1 (STK4) STK 07-116
MUSK TK 08-153
NEK1 STK 05-123
NEK2 STK 05-226
NEK6 STK 05-130
NEK7 STK 05-131
NEK9 STK 05-133
NPM1-ALK TK 08-517
p38α (MAPK14) STK 04-152
p38β (MAPK11) STK 04-153
p38γ (MAPK12) STK 04-155
p38δ (MAPK13) STK 04-154
p70S6K (RPS6KB1) STK 01-154
PAK2 STK 07-124
PBK STK 05-168
PDGFRα (PDGFRA) TK 08-157
PDGFRα (PDGFRA) [T674I] TK 08-503
PDGFRα (PDGFRA) [V561D] TK 08-507
PDGFRβ (PDGFRB) TK 08-158
PDK1 (PDPK1) STK 01-132
PIM1 STK 02-054
PIM2 STK 02-155
PKACα (PRKACA) STK 01-127
PKCα (PRKCA) STK 01-133
PKCε (PRKCE) STK 01-136
PKD2 (PRKD2) STK 02-158
PLK1 STK 05-157
PLK3 STK 05-159
PYK2 (PTK2B) TK 08-138
RET TK 08-159
RET[G691S] TK 08-522
RET[M918T] TK 08-508
RET[S891A] TK 08-523
RET[Y791F] TK 08-521
ROCK1 STK 01-109
RON (MST1R) TK 08-152
ROS (ROS1) TK 08-163
RSK1 (RPS6KA1) STK 01-149
SGK STK 01-158
SRC TK 08-173
SRM (SRMS) TK 08-174
SYK TK 08-176
TEC TK 08-182
TIE2 (TEK) TK 08-185
TNK1 TK 08-104
TRKA (NTRK1) TK 08-186
TRKB (NTRK2) TK 08-187
TRKC (NTRK3) TK 08-197
TSSK1 STK 02-364
TXK TK 08-183
TYK2 TK 08-147
TYRO3 TK 08-109
YES (YES1) TK 08-175